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Investigator, Investigative Safety and Drug Disposition - King of Prussia, PA

King of Prussia, PA
View GlaxoSmithKline Company Profile


Basic qualifications:
•Masters degree in biology, pharmacology, toxicology or related sciences with ≥5 years of relevant experience in optical microscopy imaging, or PhD in above fields with ≥2 years relevant experience.
•Demonstrated experience with optical microscopy imaging techniques across multiple platforms (confocal, flow cytometry, laser scanning cytometry, live cell imaging, in vitro and in vivo systems).
•Demonstrated proficient in designing, conducting and interpreting multi-parametric, quantitative cell based assays to investigate mechanistic safety and drug disposition questions.  
•Basic knowledge of cell biology and physiology.
•Attentive documenting laboratory details.  
•Experience applying innovation and creativity to solve complex problems.

Preferred qualifications:
•PhD in biology, pharmacology, toxicology, or related sciences.
•Experience with complex in vitro models e.g. organoid or organ-on-a-chip.
•Knowledge of cellular mechanisms of toxicity, especially in the context of drug discovery and/or development.
•Proven track record of external visibility via peer reviewed manuscripts and posters.
•Strong written and oral communication skills.
•Demonstrated high learning ability with scientific curiosity and willingness to learn about scientific areas outside direct area of expertise.  
•Demonstrated ability to work in multi-disciplinary teams, displaying effective interpersonal, communication, and negotiation skills with scientists at all levels.

•Participate as a team member in Investigative Safety and Drug Disposition (ISDD) team, part of the Mechanistic Safety and Disposition (MSD) Group in Platform Technology Sciences (PTS).
•Work on a multi-disciplinary team spanning drug disposition, toxicology and clinical development whose role it is to investigative mechanistic toxicology support to program/project teams to help make informed decisions (e.g. on-/off-target mechanism of action) on compound progression and/or clinical development plans.
•Contribute to method/capability development, conducting bespoke in vitro/ex vivo studies to characterize toxicological mechanisms of action to support Projects at all stages of development.
•Provide optical microscopy leadership and practical support within ISDD and across the MSD matrix.
•Provide authorship/review of high quality study reports, publications, and regulatory dossiers.
•Support of literature based Off Target/Target Safety Reviews.
•Search for, identify and evaluate emerging cellular models (2D/3D) and imaging platforms.
•Contextualize mechanistic investigative toxicology data and represent MSD at Program/Project Teams.
•Leverage expertise with imaging groups across the organization.
•Publish/present at internal and external meetings.

Contact information:
You may apply for this position online by selecting the Apply now button.

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  • JobId: WD107632
  • Posted / Updated: 6/14/2017