Principal Research Scientist -Sickle Cell Disease, Hematology

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Job Description

Sickle cell disease (SCD) is the most common genetic hematological disorder, accounting for over 305000 births in 2010, with millions of people currently affected across the globe, the majority in low and middle income countries. The condition can cause extreme pain, life-threatening infections and other complications such as stroke or loss of vision. The disease can interfere with many aspects of the patient’s life, including education, employment and psychosocial development resulting in significant socio-economic impact.

Do you want to be part of early drug discovery projects that can ultimately affect the treatment for Sickle Cell Disease that would have the ability to be accessible to all patients?

The Novartis Institutes for Biomedical Research (NIBR) is the innovation engine of Novartis, focusing on leveraging the breadth of innovation and novel modalities in the development of breakthrough therapies for patients. The exploratory Disease Area X (DAx) department at NIBR is looking for a highly motivated PhD-level Principal Scientist to develop innovative, transformative, in vivo therapies for Sickle Cell Disease. DAx is a highly dynamic and collaborative drug discovery department that interfaces innovative biology, genetic engineering, gene and cell therapy platforms, genome analysis, different modalities with pre-clinical development and translational medicine.

Your responsibilities include, but are not limited to:

- Will assume a crucial role in the development of novel therapeutic concepts and will contribute at all stages of a project, from inception, early project validation, optimization, candidate selection and through to early clinical development of novel medicines for patients with sickle cell disease

- Will work collaboratively with other specialists to develop project strategy, identify key drug discovery issues, propose and implement creative solutions, execute and guide teams to success and decision points.

- Propose and explore new research directions, projects, and/or new technologies. He/she will conduct early research to develop in vivo targeted gene delivery strategies for Sickle Cell Disease

- Self-motivation, ability to work independently, passion for working in an interdisciplinary, collaborative research environment

- Lead a team of associates

EEO Statement
The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum requirements

What You'll Bring to the Role:

- A demonstrable record of accomplishment of driving and supporting multiple research projects, and contributions as an author to high-impact, peer-reviewed publications in the field

- Will possess excellent oral and written communication skills and an ability to thrive in a dynamic matrix research environment.

- Creative problem-solving skills; excellent analytical, communication and organizational skills.

- Proven expertise with Hematopoietic Stem Cell Biology (HSC) biology in order to establish the in vitro and in vivo models required for establishing drug discovery programs with experience with optimizing gene delivery into HSC

Desirable Requirements:

- Ph.D. in Cellular or Molecular Biology or Immunology. Experience in hematology is preferred together with 3 to 5 years’ experience in leading an innovative research team with a focus on gene therapy

- Preference will be given to candidates with experience in gene therapy and hematologic stem cell biology in a pharmaceutical or biotechnology research setting.

Why Consider Novartis?

799 million. That’s how many lives our products touched in 2019. And while we’re proud of that fact, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people’s lives?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges.

Imagine what you could do at Novartis! Join us and help reimagine medicine.

Commitment to Diversity & Inclusion:

Novartis embraces diversity, equal opportunity and inclusion. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.