Senior Scientist, in vivo Pharmacology

Job Description

4.4 million people have sickle cell disease (SCD), which resulted in about 114,800 deaths across the globe in 2015. A number of health problems may develop, such as attacks of pain, anemia, swelling in the hands and feet, bacterial infections and stroke in SCD patients.

The Novartis Institutes for BioMedical Research (NIBR) is the innovation engine of Novartis, focusing on powerful new technologies that have the potential to help produce therapeutic breakthroughs for patients.

The Exploratory Disease Area (DAx) department at NIBR is looking for a highly motivated scientist to join the project teams to develop ground-breaking therapies for SCD and other monogenic diseases. The successful candidate will play an important role in leading pharmacology studies of LMW compounds or biologics in rodent models to support the preclinical development of innovative therapies.

Your Responsibilities include, but are not limited to:

* Working collaboratively with team members to design and execute in vivo studies to evaluate the pharmacokinetic, pharmacodynamic and efficacy features of selected candidates

* Developing disease-relevant mouse models and humanized mouse models for preclinical studies together with team members

* Performing molecular assays to investigate the effects of LMW cpds or biologics in different tissues/cell types

* Preparing study reports and presenting the results at internal meetings

EEO Statement
The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum requirements

What You'll Bring to the Role:

* Bachelor's or Master’s Degree in biology or related subject area with extensive experience in pharmacology studies in rodent models, and a strong background in pharmacology and mouse physiology

* Proficient with skills routinely used in pharmacology studies with LMW cpd's or biologics: dosing/injections via multiple routes; different blood collection methods; necropsies for tissue collection; anesthesia and euthanasia

* Experienced with general molecular techniques such as Western blotting, ELISAs, and q-PCR, etc.

* Be familiar with computer programs including MS Word, Excel, PowerPoint, and GraphPad Prism

* Candidate is a demonstrated team player, has strong analytical and communication skills, and has the enthusiasm and drive to learn new skills. She/he will also be required to maintain a well-organized notebook.

Desirable Requirements:

* Hands-on experience in humanized mouse models, AAV vectors and transduction, cell culture, transfection and flow cytometry is preferred

Why consider Novartis?

769 million. That’s how many lives our products touched in 2020. And while we’re proud of that fact, in this world of digital and technological transformation, we must also ask ourselves this: how can we continue to improve and extend even more people’s lives?

We believe the answers are found when curious, courageous and collaborative people like you are brought together in an inspiring environment. Where you’re given opportunities to explore the power of digital and data. Where you’re empowered to risk failure by taking smart risks, and where you’re surrounded by people who share your determination to tackle the world’s toughest medical challenges.

Imagine what you could do at Novartis!

Commitment to Diversity & Inclusion:

Novartis is committed to building an outstanding, inclusive work environment and diverse team’s representative of the patients and communities we serve.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.