Director - Bispecific Antibodies

Do you have a passion for Science? Would you like to apply your expertise to impact a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.

About AstraZeneca in Gaithersburg, MD

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams.

Summary of the Group

Antibody Discovery & Protein Engineering (ADPE) is responsible for the discovery and optimization of next generation biologics to create biological drug candidates for all key therapeutic areas such as oncology, respiratory and inflammation, cardiovascular, renal and metabolic diseases. We're constantly pushing the boundaries of science to deliver life-changing medicines to patients, with a passion for the development of in-house biologics discovery platforms and novel drug modalities to address unmet medical needs.

Main Duties & Responsibilities

We are seeking a talented and highly-influential leader to effectively direct and manage a multidisciplinary team of highly experienced scientists and deliver bispecific programs into the pipeline. In this role, you will collaborate with project leaders across all therapeutic areas to understand the target biology and to directly steer and influence discussions and decisions related to developing an appropriate drug modality. As a recognized leader with a proven publication track record in the field of protein engineering and antibody drug development, you will expand existing bispecific platform technologies and drive scientific innovation contributing to AstraZeneca pipeline progression. While working productively and proficiently in a highly dynamic, scientifically rigorous and fast-paced environment, you will effectively represent the department in cross-functional meetings, governance committees and due diligences.
  • Lead and expand a team of scientists to advance innovative bispecific technologies and support bispecific pipeline progression
  • Collaborate and work closely with scientific leads across all therapeutic areas to ensure timely progress of pipeline projects and drive technological innovations
  • Direct and progress bispecific programs from early discovery to development stage
  • Establish high-level of scientific innovation and develop bispecific technologies for enhanced selectivity, improved developability, and reduced off-target and off-organ toxicities to ensure scientific excellence and effective achievement of research goals
  • Track record of strong scientific publications, inventorship on patents and presentations at major conferences

Education & Experience Requirements

PhD in Biotechnology, Biochemistry, Molecular Biology or other relevant scientific field with 10+ years of experience in antibody engineering and/or bispecific antibody technologies in the Biotech or Biopharmaceutical industry

Required Skills
  • Proven record in antibody drug development and driving bispecific programs from early discovery into development stage
  • Established ability to lead a team, setting goals and objectives, motivate and develop others and influence recruitment of high performing staff
  • Extensive hands-on experience in molecular biology, antibody design and engineering and characterization of various bispecific antibody formats
  • Demonstrated ability to influence and build strong relationships with internal and external collaborators while working effectively in a collaborative team environment across multiple functions
  • Track record of problem solving, risk management, negotiating and influencing skills
  • Strong industry leadership experience, excellent written and verbal communication skills and effective presentation of complex scientific reports to cross-functional and senior management teams are essential for this role

Desired Skills
  • Strong background in immunology, T cell biology and cancer biology
  • Experience in structure/function-based techniques, including crystallography, Cryo EM
  • Deep understanding of various imaging/multicolor flow cytometry-based instruments and data analysis programs
  • Experience in antibody discovery using one of several display-based technologies is preferred but not essential
  • Experience in development of in vivo mouse models and subsequent analysis for efficacy and PK

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.

So, what's next?

Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it's yours.

Where can I find out more?

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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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