Director of Human Pluripotent Stem Cell and Genome Engineering Laboratory


The Institute for Precision Health (IPH) at UCLA seeks an
innovative director to build and lead a Stem Cell and Genome Engineering
Laboratory. The goal is for the leader to design, construct, develop services,
and operationalize the core lab into a cutting-edge program supporting the
mission of the institution. The primary focus will be on production of induced
pluripotent stem cells (iPSCs) from human subjects/patients and the use of
site-specific endonucleases to directly modify the human genome in cultured
cells with a focus on pluripotent stem cells. Considering this is a rapidly
evolving field, appropriate research and development technologies need to be
put in place to ensure the core remains at the state of the art.

In this role, you will be responsible for the overall operation and
administration of the lab, including the management of core lab staff and
services, supervising the scientific staff developing human pluripotent stem
cell models and performing CRISPR-mediated gene editing. Communication with the
core lab clients will be important for maintaining high customer-satisfaction
and ensuring daily operations run smoothly. You will also be responsible for communicating
progress and results with core customers promptly, accurately and proficiently
assuring compliance with the applicable regulations.

In addition to managing the overall operational, budgetary,
and financial responsibilities and activities of the core lab, you will provide oversight and direction to the employees in the core lab in
accordance with the UCLA policies and procedures. You will coach, mentor, and
develop staff, including overseeing new employee onboarding and providing career
development planning and opportunities. You will report to the scientific director of the
core lab and lead the research studies semi-independently, including project
planning, performance and management, preparation of scientific reports, abstracts
and publications.

*Contract, may become career
  • A Ph.D. is strongly preferred
  • 5+ years of research experience with models of
    cell culture, gene modification methods, molecular biology and human iPSC
    generation and/or CRISPR-based genome editing.
  • Extensive
    experience in recombinant DNA techniques, PCR, cell culturing techniques,
    multicolor flow cytometry, and/or bioinformatics and genomics, as it relates to
    validation of genetic modifications.
  • Basic
    experience with genomics approaches such as RNA-sequencing and whole genome
    sequencing and immunostainings to guide the basic characterization of iPSC
  • Ability to
    oversee and coordinate several projects simultaneously.
  • Excellent
    verbal and written communication skills. Should be able to adapt communication
    style to suit different audiences and ensure main action points are
    communicated to stakeholders.
  • Ability to
    interact effectively with bioinformaticians to understand and direct the
    analysis of genomics data relating to the characterization of iPSC lines,
    CRISPR-targeting events and pooled CRISPR- screens.
  • Action
    orientated. Should be able to follow up on feedback to ensure positive
  • Ability to
    design and supervise genome-wide, pooled CRISPR screens.
  • Ability to
    learn and incorporate scientific advances to improve the capacity of the core
    and keep the core at the cutting edge.
  • Previous
    experience running laboratory operations is highly preferred, but not required.
  • Strong
    technical knowledge of laboratory science and supply chain.
  • Proven
    success in leading change, developing talent, and service excellence.
  • Inspiring
    leadership presence and emotional intelligence with the ability to influence at
    all levels across the organization.

UCLA is an Equal Opportunity/Affirmative Action employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or protected Veteran status.