Principal Scientist, Bioanalytical Expert, PK Sciences

Job Description

100,000 + people across 140 countries are working for Novartis to discover, develop and successfully market innovative products to prevent and cure diseases, to ease suffering, and to enhance the quality of life! If you are curious, scientifically minded, and want to positively impact society by speeding delivery of novel therapies to patients, then look no further, NIBR is the place to be. As a Principal Scientist in the Translational Medicine PK Sciences Bioanalytical Labs group, you will have the opportunity to make a difference. If you have a collaborative nature, a commitment to teamwork across an organization and a relentless focus on improving patient care we want you to apply.

In this laboratory-based Principal Scientist role, you will apply your hands-on expertise to the bioanalysis of small and large molecule therapeutics. You will be part of a dynamic BA Labs team, deeply engaged in progressing drug discovery programs. In this role, you will contribute to the pharmacokinetic understanding of small and large molecules and the development of suitable methods, as part of the optimization and characterization process of candidate compounds of therapeutic relevance.

Your main responsibilities will include:

• Work in a collaborative laboratory environment on advanced LC-MS based method development and sample analysis. Evaluate and interpret bioanalytical data and results from Discovery Pharmacokinetic and Pharmacodynamics (PK/PD) studies. Perform the Non-Compartmental analysis (NCA) to be included in the complete summary report.
• Primary role will be to work on challenging low molecular weight, peptide, protein and new modality Discovery drug candidates across all therapeutic areas.
• Help manage the outsourcing of the Bioanalysis for the more routine compounds to our partner CROs.
• Design and perform bioanalytical experimental work independently and engage collaboratively in challenging research questions with partner drug discovery scientists.
• Provide process and technical improvements to bioanalytical procedures to increase throughput and efficiencies while maintaining high quality and fit for purpose accuracy of laboratory measurements. Introduce and evaluate new technologies and innovative methods of analysis, in collaboration with internal and external stakeholders.
• Represent the bioanalytical function on project teams and present results, data interpretation, timelines etc. at project team meetings.
• Present results internally/externally.

EEO Statement
The Novartis Group of Companies are Equal Opportunity Employers and take pride in maintaining a diverse environment. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We are committed to building diverse teams, representative of the patients and communities we serve, and we strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Minimum requirements

What you bring to the role:

• M.S. or Ph.D. in chemistry, biochemistry or related field with minimum 3 years of relevant lab experience in a pharmaceutical, CRO or related industry.
• Advanced hands-on experience in bioanalytical sample preparation, LC-MS method development, and sample analysis.
• General knowledge of pharmacokinetic data relevance and interpretation in a drug discovery environment. Be familiar with concepts of data handling and interpretation.
• Excellent planning, organization, and time management skills including the ability to support and prioritize multiple projects, and the ability to adapt to changing priorities and deadlines.
• Strong interpersonal communication skills, presentation skills and ability to thrive in a dynamic matrixed working environment.

Why Novartis?

769 million lives were touched by Novartis medicines in 2020, and while we’re proud of this, we know there is so much more we could do to help improve and extend people’s lives.

We believe new insights, perspectives and ground-breaking solutions can be found at the intersection of medical science and digital innovation. That a diverse, equitable and inclusive environment inspires new ways of working.

We believe our potential can thrive and grow in an unbossed culture underpinned by integrity, curiosity and flexibility. And we can reinvent what's possible, when we collaborate with courage to aggressively and ambitiously tackle the world’s toughest medical challenges. Because the greatest risk in life, is the risk of never trying!

Imagine what you could do here at Novartis!