Scientist, DMPK

Job Description

Biogen is seeking a highly motivated, results driven Scientist I to join the Drug Metabolism and Pharmacokinetics (DMPK) department at our Kendall Square site in Cambridge, Massachusetts. Biogen’s DMPK group includes combined modelers/project representatives to support preclinical research and development covering a mixed modality portfolio of discovery and early development projects.

The position requires expertise in several challenging areas: modeling and simulation, ADME, primary pharmacology, knowledge of neuroscience, etc. The ideal candidate willapply a range of fit for purpose modeling and simulation approaches specific to the unique pharmacology and pharmacokinetics across a broad range of discovery projects.

Responsibilities
  • Hands-on application of a range of modeling and simulation approaches (empirical PK/PD, PBPK, and systems pharmacology) to project teams to support and influence critical decisions in drug discovery and development, including target selection, lead optimization, clinical candidate selection, and early clinical development.
  • As a core team member, collaborate with multidisciplinary preclinical and clinical project teams to develop translational pharmacology plans to provide the quantitative platform of evidence for robust clinical hypothesis testing.
  • Collaboration with clinical colleagues to facilitate the transfer of quantitative knowledge necessary for the rational design of early clinical development plans.
  • Keep up to date with emerging literature and science in disease relevant pharmacology, DMPK and mathematical modeling.


Qualifications

  • PhD with 1 year of post-doctoral or industrial experience
  • Demonstrated proficiency in translational PK/PD modeling or PBPK modeling as evidenced by a publication/presentation record.
  • Experience with complicated data types and a diversity of modeling and simulation approaches (e.g. PKPD, PBPK, Systems Pharmacology) and M&S platforms (e.g. Phoenix, Gastroplus, SimCYP)
  • Experience in applying M&S and PBPK modeling within neurological disease areas across a range of modalities including small/large molecules. Experience with PK and/or PK/PD models with gene therapy is a plus.




Additional Information

Biogen’s US Alzheimer’s Franchise is looking to recruit proven and ambitious sales achievers with at least five years of experience in pharma, specialty, hospital, med device/capital equipment, and/or biotech sales.
In this field-based, specialty sales representative position you will be called upon to sell our products with key stakeholders in the Alzheimer’s Disease community: including Neurologists and allied health professionals.

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