Associate Scientist, Analytical Development

Do you have a passion for Science? Would you like to apply your expertise to impact a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might be the one for you!

At AstraZeneca, we put patients first and strive to meet their unmet needs worldwide. Working here means being entrepreneurial, thinking big and working together to make the impossible a reality. If you are swift to action, confident to lead, willing to collaborate, and curious about what science can do, then you're our kind of person.

About AstraZeneca in Gaithersburg, MD:

Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all designed to inspire collaboration and cross-functional science. We believe employees benefit from being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.

The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you'll find newly-designed, activity-based work spaces to suit a variety of working styles while increasing collaboration between teams.

Summary of the group:

Analytical Sciences is a global multifunctional team within AstraZeneca biopharmaceutical development tasked with the development, execution, and transfer of analytical methods intended to characterize and release pharmaceutical products. The residual impurity team within analytical sciences develops methods focusing on ELISA or PCR methods for the detection of impurities and for genome content in biopharmaceutical materials.

Main Duties & Responsibilities:
  • Development of ELISA or qPCR based methods for detection of a variety of analytes in biopharmaceutical materials. This will include initial POC work through SOP finalization and method transfer.
  • Design conduct method verifications/qualifications/validations in accordance to the ICH guidelines to enable utilization in a cGMP environment. This will include initial authoring of study plans through finalization of final reports
  • Routine laboratory testing of samples to support the AstraZeneca drug development pipeline. This will include keeping accurate records of laboratory activities, maintaining and qualification of critical reagents, and scheduling and prioritization of testing.
  • Participation in a variety of CMC tasks related to assigned projects. This will involve preparation of technical reports and data summaries for presentation.
  • Collaboration with CMC functions across biopharmaceutical development including upstream (fermentation), downstream (purification), formulation, regulatory, quality, and project management. This will include communication of data and strategies, authoring of IND, IMPD, BLA, etc sections, and resource planning for new pipeline projects.
  • Ability to adapt to new pharmaceutical modalities by rapid adaption of new technologies and techniques. This will include continuous survey and implementation of analytical techniques and strategies for detection of impurities in CAR-T, In-vivo expressed biologics (mRNA, AAV, DNA), and other virus based pharmaceuticals.

Education & Experience Requirements:

Minimum of a BS degree in relevant field

1+ years of relevant experience preferred

Required Skills:
  • ELISA, qPCR method development
  • General Laboratory Skills: Pipetting, BSC usage, LIMS usage
  • Computer Skills: MS Excel, Powerpoint, Word, Softmax (or similar)

Desired Skills:
  • qPCR, ddPCR, DNA sequencing (Sanger/NGS)
  • Viral titer testing by qPCR
  • Homogeneous immunoassay development (AlphLISA, TR-FRET, etc)
  • Project management experience in the biopharmaceutical industry
  • Automation, Automated liquid handling (Hamilton Star preferred)

Why AstraZeneca?

At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we're opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together. Interested? Come and join our journey.

So, what's next!

Are you ready to bring new ideas and fresh thinking to the table? Brilliant! We have one seat available and we hope it's yours.

Where can I find out more?

Check out our landing page for more information on our BPD group

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AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorisation and employment eligibility verification requirements.

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