Associate Scientist III, Gene Therapy – Ophthalmology

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Job Description

About This Role
Biogen’s Gene Therapy Accelerator Unit (GTxAU) is driving innovation on both technology and drug discovery process fronts to accelerate gene therapies that may one day help transform the way we treat neurological diseases. We are looking for an innovative, enthusiastic, and dedicated scientist to join our ophthalmology performance team and contribute to the generation of pioneering gene therapies for saving vision.

You will work independently and with cross-functional teams to develop and perform molecular and cell-based assays to characterize AAV vectors in vitro as well as support in vivo characterization. Your work supports the development of novel therapeutic approaches for neurodegenerative, neuroinflammatory, and ophthalmic disorders.

What You’ll Do
  • Design and characterize best-in-class gene therapy vectors for select ocular indications
  • Investigate & implement cell-based models/assays to inform selection of retinal gene therapy candidates
  • Characterize the properties of novel AAV capsids and other gene transfer vectors following intraocular delivery in relevant species
  • Collaborate extensively with other research units to advance proof-of-concept studies
  • Establish SOPs and adapt new protocols from literature
  • Maintain electronic laboratory notebooks, present data to the team, and write study reports

Who You Are
You are passionate about gene therapy research and use your scientific curiosity to drive novel discoveries. You are a forward-thinker, motivated to learn new skills, and are a team player who strives to make an impact on patients’ lives.

*LI-RD8

Qualifications

Required Skills
  • MS or BS in biology, biochemistry, biotechnology, or related field
  • 3+ years (BS) or 1+ year (MS) of experience in an academic or biotech/pharmaceutical industry setting
  • Hands-on experience with molecular biology techniques (qPCR, ddPCR, DNA gel electrophoresis, SDS-PAGE, WB, ELISA, immunohistochemistry, etc.)
  • Strong skillset in mammalian cell culture
  • Ability to independently design, execute, and analyze in vitro molecular biology experiments
  • Strong critical thinking, communication, organization, and presentation skills

Preferred Skills
  • Hands-on experience with AAV or other gene therapy vectors
  • Previous experience in maintaining retinal cell models including iPSC-derived cell types
  • Previous experience with cell-based reporter assays (fluorescence, luminescence)
  • Previous experience with genome engineering approaches such as CRISPR/Cas9
  • Previous experience with murine ophthalmological endpoint measures including visual/behavioral assays, fundus & OCT imaging, retinal dissection, and histological analyses
  • Hands-on experience with murine intraocular delivery methods (intravitreal, subretinal, and/or suprachoroidal)
  • Hands-on experience with molecular cloning, plasmid isolation/QC, and DNA sequencing methods
  • Research experience in ophthalmological or neurodegenerative diseases




Additional Information

Biogen’s US Alzheimer’s Franchise is looking to recruit proven and ambitious sales achievers with at least five years of experience in pharma, specialty, hospital, med device/capital equipment, and/or biotech sales.
In this field-based, specialty sales representative position you will be called upon to sell our products with key stakeholders in the Alzheimer’s Disease community: including Neurologists and allied health professionals.

849265022