Senior Scientist

Job Description

If this position will be based in the US or Puerto Rico (not applicable to positions based outside of US or Puerto Rico): Subject to applicable law, all prospective hires will be required to demonstrate that they have been fully vaccinated for COVID-19 or intend to be vaccinated for COVID-19 by November 1, 2021, or qualify for a medical or religious accommodation to this vaccination requirement. Hired candidates who are not vaccinated by November 1, 2021, and who have not been approved for a legally-required medical or religious accommodation will be subject to disciplinary action up to and including termination of employment, subject to applicable law

Target discovery is critical to the success of drug discovery. Using innovative thinking, state-of-the-art facilities, and robust scientific methodology, we collaborate to discover the next medical breakthrough. The Neuroscience Department is seeking a highly motivated and experienced Senior Scientist with a strong background in Molecular Cell Biology and Neuroscience to join us at West Point, PA site for this endeavor. The successful candidate would have in-depth knowledge of neurodegenerative research and target validation. He or she will design and implement in-vitro and cell-based experiments using genetic and pharmacological manipulation of pathways in relevant systems to validate novel targets and characterize the mode of action of tool molecules. In this role, he or she will also study the scientific literature, develop new technical expertise, and participant in scientific dialogue in project meetings and internal/external scientific meetings. The candidate must enjoy laboratory work and thrive in a team environment to build strong relationships within highly collaborative, multidisciplinary groups to effectively execute drug discovery.

Educational and experience requirements
  • Ph. D. in Biology or related field or M.S. with 3+ years of experience or B.S. with 5+ years of working experience in pharma, biotech, or academic setting.

Required skills and experience
  • A background in in-vitro and cell-based assay development and familiarity with Immunoassay or luminescence-based detection approaches.
  • Proficiency in molecular biology techniques, such as qPCR, Western blot, ELISA/MSD, etc.
  • Knowledge and experience in cell culture, primary neuron culture and iPSC neuron culture; experience working with animals for in-vivo work is a plus.
  • A track record of achievement in independently designing and executing experiments;
  • Excellent attention to detail and strong communication (oral and written) skills

Preferred skills and experience
  • Experience in working with animal models of neurodegenerative diseases.
  • Experience in image-based techniques, e.g. Immunocytochemistry, Immunohistochemistry, or high-content imaging.
  • Experience in functional genomics methods, such as siRNA, shRNA, CRISPR/Case9 or RNA splicing.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we "follow the science" that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are ...

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for ...

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.


In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

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US and Puerto Rico Residents Only:

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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:


VISA Sponsorship:

Travel Requirements:
No Travel Required

Flexible Work Arrangements:
Work Week

1st - Day

Valid Driving License:

Hazardous Material(s):

Number of Openings:

Requisition ID:R142040