Senior Scientist, LGR Functional Genomics

Site Name: USA - California - San Francisco Posted Date: Oct 27 2021 “Technology is key to our innovation strategy at GSK, and CRISPR is one of the most important technologies of our time.” Dr. Hal Barron - Chief Scientific Officer and President GSK R&D Are you a curious, collaborative, and driven scientist interested in using biology's most powerful new tool to understand the genetic regulators of complex diseases? The Laboratory for Genomic Research (LGR) is a new functional genomics center on the UCSF Mission Bay campus in San Francisco, CA, representing a novel hybrid model that brings together researchers from UC Berkeley, UC San Francisco, and GlaxoSmithKline under a single roof to work on projects both together and independently. The new laboratory will house up to 40 scientists, 12 of whom will be GSK employees working closely with our UC partners to develop and apply CRISPR-Cas based functional genomics technologies to collaborative research projects. The outputs of these projects will be focused on technologies, new drug targets, and elucidating biological mechanisms that will foster both academic and industrial advances. As a GSK laboratory scientist, you will be responsible for supporting collaborative and GSK-only projects at the LGR. Working in a dynamic and innovative academic-industry environment, this laboratory-based role will give you the opportunity to: Apply CRISPR-Cas nuclease, inhibition, and activation-based approaches to target discovery and validation Develop new cell models and assays to address some of biology's toughest questions Work with world-renowned investigators from GSK, UCSF, and Berkeley Support enabling technologies including scRNA-seq, high content imaging, and robotic-enabled pooled and arrayed screening Develop broad expertise and be involved with some of the most important biological research taking place today Why you? Basic Qualifications: We are looking for professionals with these required skills to achieve our goals: Bachelor's or Master's degree in biological or chemical sciences 3 or more years of research experience Bench-facing laboratory experience, including : basic molecular biology techniques and cloning sterile technique and mammalian cell culture skills Preferred Qualifications: If you have the following characteristics, it would be a plus: Genome editing or functional genomics screening experience Fluency with next-generation sequencing techniques (single cell sequencing a plus) Hands-on experience working with primary cells, iPSC-derived cell types, and/or 3D complex cell models (e.g., spheroids, organoids) Lentiviral production and/or cell engineering experience Hands-on experience with advanced imaging modalities including flow cytometry, confocal imaging, and/or high content imaging Experience and interest in working with automation equipment Works well in a team environment Quick and self-motivated learner Strong track record of delivery Excellent verbal and written communication skills Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being. Building strong relationships and collaboration, honest and open conversations. Budgeting and cost-consciousness. 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