Scientist I, ASO Process Development and Manufacturing

Job Description

About This Role

We are seeking a highly motivated and creative individual to join our Oligonucleotide Chemical Development team. This position provides an exciting opportunity to develop robust processes for the synthesis of oligonucleotides. This position provides an exciting opportunity to gain hands-on experience and exposure to the design and development of manufacturing processes for clinical and commercial therapeutics.

  • Collaborate with development and manufacturing teams to design and conduct laboratory experiments to optimize and/or characterize the synthesis processes of oligonucleotides with an emphasis on improvement in process robustness and productivity and control of impurities.
  • Perform pilot-scale syntheses to produce oligonucleotide compounds for purification process development and/or preclinical studies.
  • Record the experimental procedures and data accurately.
  • Communicate research results effectively by writing research reports and presenting data in team meetings.
  • Engage in the CMC activities including authoring CMC section of INDs.
  • Manage Contract Research Organization (CRO)

Who YouAre

You are someone who is passionate for exploring novel scientific ideas and play a key role in developing new cutting-edge technologies with a vision to push Biogen’s state-of-art science in oligonucleotide synthesis that can ultimately impact patient lives.
  • Areas of specialization reside in the fields of synthetic organic chemistry with excellent synthetic skills and a deep understanding of reactivity and reaction mechanisms.
  • Must have the abilities to work both independently and collaboratively within a team environment and effectively communicate in written and oral forms.
  • The individual must be self-driven, an independent thinker, vigorous and thorough in conducting experiments, collecting and interpreting data, drawing conclusions, and making recommendations.
  • Beyond graduate work in synthetic organic chemistry


  • Ph.D. with 0-3 years of relevant postdoc experience.
  • M.S. with4+ years of relevant experience in pharmaceutical or biotech settings.
  • BS with 6+ years of relevant experience in pharmaceutical or biotech settings

Required Skills
  • Perform synthetic process research and development of drug candidates including conjugates and starting materials beyond platform oligonucleotides by using information from literature, conferences, seminars etc.
  • Draft patent applications and manuscripts for publications.
  • Initiate innovative research projects to improve synthesis processes.

Preferred Skills
  • Experience in nucleoside chemistry or oligonucleotide synthesis
  • Experience in API synthesis process development

Additional Information

Biogen’s US Alzheimer’s Franchise is looking to recruit proven and ambitious sales achievers with at least five years of experience in pharma, specialty, hospital, med device/capital equipment, and/or biotech sales.
In this field-based, specialty sales representative position you will be called upon to sell our products with key stakeholders in the Alzheimer’s Disease community: including Neurologists and allied health professionals.