Associate Scientist - Protein Expression and Cell Biology


You've earned your degree. How will you use that achievement to reach your goals? Do more with the knowledge you've worked hard to acquire and the passion you already have. At Amgen, our shared mission-to serve patients-drives all that we do. It is key to our becoming one of the world's leading biotechnology companies, reaching over 10 million patients worldwide. Become the professional you are meant to be in this meaningful role.

Associate Scientist - Protein Expression and Cell Biology


What you will do

Let's do this. Let's change the world. In this scientific role, you will conduct recombinant protein expression using mammalian expression systems. Amgen's Therapeutic Discovery organization is seeking a hard-working, team-orientedAssociate Scientistto join the Protein Technologies group at our South San Francisco site. Protein Technologies designs and generates drug discovery program-enabling reagents to support therapeutic programs and innovative modalities. The candidate will work closely with protein expression staff, as well as colleagues in protein engineering, cloning and purification groups.

Responsibilities include:
  • Expression of recombinant proteins using mammalian cell hosts (e.g. bi-specific mAb, diverse secreted and membrane-anchored proteins in CHO and HEK cells)
  • Small-scale high-throughput transient and stable pool expression
  • Resolving protein expression challenges by collaboration, reading literature, and implementing novel methods
  • Performing small to larger-scale (30L) protein production runs, analyzing harvested culture media by SDS-PAGE, Western blotting, Octet, etc. to determine secretory titer and protein product quality
  • Summarizing and reporting results according to record keeping requirements (e-notebook, LIMS)
  • Contributing to technology development initiatives through conceptualization, experimentation and implementation


What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The scientific professional we seek is innovative with these qualifications.

Basic Qualifications
  • Bachelor's Degree in Biochemistry, Bioengineering, Cell Biology, Molecular Biology, or a related subject area, and 4 years of scientific laboratory experience OR
  • Master's Degree in Biochemistry, Bioengineering, Cell Biology, Molecular Biology, or a related subject area and 2 years of scientific laboratory experience

Preferred Qualifications
  • Prior experience in recombinant protein production using mammalian expression systems in biotech/pharma industry
  • An ability to solve complex problems and to work both independently and in teams
  • Extensive hands-on experience in one or more of the following areas:
  • Cell line and cell phenotype engineering using HEK 293 and/or CHO cells
  • Producing secretory molecules such as bi-specific and multi-specific antibodies
  • Robotic liquid handling (e.g. TECAN) and high-throughput protein expression
  • Running Wave or other bioreactors with disposable vessels at 5-30L scale
  • Effective verbal and written communication and interpersonal skills and ability to work in a fast-paced environment.


Some of the vast rewards of working here

As we work to develop treatments that take care of others, so we work to care for our teammates' professional and personal growth and well-being.
  • Full support and career-development resources to expand your skills, enhance your expertise, and maximize your potential along your career journey
  • A diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act
  • Generous Total Rewards Plan-comprising health, finance and wealth, work/life balance, and career benefits-with compensation and benefits rated above 4 stars (out of 5) on Glassdoor

Apply now

for a career that defies imagination

Objects in your future are closer than they appear. Join us.

Join Us

If you're seeking a career where you can truly make a difference in the lives of others, a career where you can work at the absolute forefront of biotechnology with the top minds in the field, you'll find it at Amgen.

Amgen, a biotechnology pioneer, discovers, develops and delivers innovative human therapeutics. Our medicines have helped millions of patients in the fight against cancer, kidney disease, rheumatoid arthritis and other serious illnesses.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other but compete intensely to win. Together, we live the Amgen values as we continue advancing science to serve patients.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.

Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.

Amgen requires all staff in the United States and Puerto Rico to be vaccinated from COVID 19 as a condition of employment. In accordance with applicable law, Amgen will provide reasonable accommodations to staff members who qualify on the basis of a medical reason or a sincerely held religious belief, practice, or observance. Such accommodation may not pose an undue hardship to Amgen, its operations, or its staff.