Principal Scientist

Job Description

New hires based in the US & Puerto Rico will be required to demonstrate that they have been fully vaccinated for COVID-19 or qualify for a medical or religious exemption or accommodation to this vaccination requirement, subject to applicable law.

We're seeking an innovative, highly motivated leader, and experienced Senior level Immunologist to join the Infectious Disease and Vaccines department at our research site in West Point, PA. The candidate will have a primary role leading teams responsible for the discovery and development of vaccines and therapeutics in the areas of Infectious Disease andCancer Immunotherapies. Successful candidates will focus on investigating novel therapeutic avenues for infectious and/or immunological diseases using humoral and T cell-based approaches. The candidate should be a thought leader in their area of expertise. They should have a strong background in T and B cell biology, cutting-edge methodologies to interrogate specificity and effector functions, and experience in human and NHP immune-biology. Knowledge of immune regulatory pathways in infectious disease and cancer are desirable. The candidate will be expected to lead, design, execute, and analyze experiments and should have advanced knowledge of immunological techniques. We value creative-thinking, teamwork, and independent analytical problem solving. If you are a highly motivated leader and a team player with a strong desire to impact basic research and translational medicine, we invite you to consider joining our mission.

  • PhD with postdoctoral experience in Immunology with a minimum 4 years of experience in industry and/or academia in a project/laboratory leading role for immune-based programs.
  • Experience in vaccine development highly desirable.

  • Proven track record in immunological and molecular techniques, including cell culture B- and T-cell purifications, ELISA, ELISPOT, flow cytometry, PCR, and will demonstrate experience with probing in vivo immune responses in pre-clinical model systems using immunoprofiling platforms.
  • Proficient in protein biochemistry, cellular assays, and cellular-marker discovery and development, and will have knowledge of infectious disease and immune-cell biology.
  • Solid computer skills, excellent written and oral communication skills, and demonstrate the ability to work collaboratively in a team environment.
  • Independent experimental design and execution, analytical problem-solving capabilities.
  • Demonstrated record of publication in peer-reviewed scientific journals.
  • Thought leader in the field of immunology and translation to medicine.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we "follow the science" that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are ...

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for ...

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization.


In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

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US and Puerto Rico Residents Only:

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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another's thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

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Requisition ID:R153745