Research Fellow, Cryo-EM Structural Biologist
About This Role
We are looking for a Research Felow with cryo-EM structural biology background and an interest in structure-based design of antibodies and gene therapy vectors to join our multi-disciplinary team. We have in-house high-resolution structural biology technologies, including a Glacios cryo-EM microscope equipped with a BioQuantum K3 detector. This is a great opportunity to work with dedicated, innovative scientists focusing on biologics and gene therapy drug discovery.
What You’ll Do
· You will use a multi-disciplinary approach that includes preparative purification of antigen-antibody complexes and state-of-the-art biophysical and structural techniques.
· Your primary responsibility will be determining novel cryo-EM structures of antigen-antibody complexes and AAV capsids.
· You will drive insights about mechanism of action and structure-function relationships and, when necessary, utilize that knowledge for engineering purposes.
· You will enjoy being part of a fast-paced and innovative team of scientists actively pursuing unmet medical needs in the neuroscience space.
Who You Are
You are passionate about structural biology and driving cryo-EM insights to impact drug discovery projects. You love learning new technological skills and working through collaboration.
Our mission to find therapies for neurological and rare diseases is a unique focus within our industry and this shared purpose is what connects us as a team. We work together to overcome obstacles and to follow the science. We are resilient as we strive to make an impact on our patients’ lives and on changing the course of medicine. Together, we pioneer. Together, we thrive.
· Ph.D. degree in Biophysics, Biochemistry or related discipline and ability to commit to an 18-month long industry research fellowship based in Cambridge, MA.
· Assessing protein complexes through purification or biophysical techniques
· All aspects of single particle Cryo-EM, including sample/grid preparation, data collection, image processing, and building 3D models of macromolecular complexes
· Working experience with Linux and High Performance Computing cluster
· Skilled at multi-body and focused refinement strategies of flexible complexes
· Interest in learning methods in protein engineering
· Ability to work independently as well as in a team environment
· Be responsible, organized, and possess strong attention to detail
· Effective communication and interpersonal skills
· Legal authorization to work in the U.S.
All your information will be kept confidential according to EEO guidelines.