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Job Details


Senior Principal Scientist - Protein Design



Full Time

On Site


San Diego, California, United States

Job Description

4 FDA approved drugs; 15+ clinical candidates; 400+ patents; more than two decades making of history! For over 21 years, the Novartis Institute for BioMedical Research (NIBR San Diego) has been doing cutting-edge innovative drug discovery.

Join us to make a difference in the next twenty years!

The NIBR-Biologics Center in San Diego seeks an experienced protein engineer to lead innovative approaches in protein design within a team responsible for the application of modern protein engineering and data science techniques to next generation biotherapeutic platforms, ranging from gene therapy to multi-specific antibodies. The successful candidate will play a key role in advancing state-of-the-art biologics within the Novartis pipeline, contributing both understanding and influencing the science of the global NIBR organization.

Your responsibilities:
• Lead a group of protein designers and data scientists, with protein engineering responsibility in NIBR biotherapeutics prioritized platforms, including adeno-associated virus gene therapy, enzyme engineering and siRNA delivery.
• Collaborate with teams of biologics, protein and structural scientists to create the necessary workflows to validate hypotheses and characterize novel designs to enhance binding, activity, and specificity.
• Evaluate, implement, and prioritize internal and external advances in structure and data driven approaches to biologics design, recognize risks and propose mitigation or contingency plans.
• Communicate and guide project teams and other core technology groups within NIBR to effectively advance molecules toward clinical trials
• Mentor scientists and develop talent, creativity, communication skills, and accountability within the organization.