Director, Clinical Biomarker Lead - Dermatology
Are you passionate about science and wanting to make a difference to patients’ lives?
Clinical Pharmacology & Experimental Medicine (CPEM) serves as a translational bridge between GSK research units and late clinical development. We leverage expertise in human disease, clinical pharmacology, biomarkers, imaging, and experimental medicine to define the optimal destination for cutting edge science to impact patient lives. It is under this umbrella that Clinical Biomarkers resides.
At GSK science is at the heart of everything we do. Join us to translate that great science into therapies as Director, Clinical Biomarker Lead-Dermatology.
In this role, you will have responsibility for development and effective implementation of biomarker and precision medicine strategy in support of clinical development of assets. Working as part of the early development / medicine development matrix teams (EDT/MDT), the Clinical Biomarker Leader will establish clear decision-making criteria to enable informed clinical decisions, identify patient segmentation strategies and integrate the strategy into the clinical development plans. You will employ cutting edge technologies and methods to discover and clinically validate biomarkers. The implementation of the biomarker strategy as part of a well thought through clinical plan will ensure optimally informed decision making in drug development and identification of the right patient population for our medicines.
This role will provide YOU with the opportunity to progress YOUR career, and your responsibilities include:
Develop and deliver biomarker strategies including approaches to pharmacodynamic biomarkers, proof-of-mechanism biomarkers, for clinical phase programs to enable informed clinical decisions.
Develop and deliver precision medicine strategy to identify predictive biomarkers to enable clinical success.
Represent biomarker strategy at EDT/MDT, study teams and at internal governance reviews as well as serve as biomarker point of contact for clinical studies.
Ensure alignment of biomarker outputs with clinical team to meet study requirements.
Lead writing of reports to support study teams and regulatory submissions as well as contribute to publications.
As required, supporting the expansion of mechanism and disease understanding to generate insights that can be leveraged for indication expansion and scientific exchange.
We are looking for professionals with these required skills to achieve our goals:
Minimum of 5 years relative experience with strong background in translational research and experience/track record in the application of biomarkers in clinical trials.
Must have disease area experience in dermatology.
Scientist and/or Physician (PhD, MD or equivalent).
Expertise in a specific research area/biomarker technology.
Experience in conducting clinical trials and working as part of a clinical study team.
Experience in cellular/molecular biology technologies, techniques, and data analysis.
Ability to analyze and interpret molecular data sets.
Ability to solve problems.
Strong writing and presentation skills.
Strong interpersonal skills and ability to thrive in a team setting.
Ability to influence teams and key leaders with a proven track record of success.
If you have the following characteristics, it would be a plus:
Experience in High dimensional dataset analysis.
Experience in conducting clinical trials and working as part of a clinical study team including working to GCP principles.
Experience with identifying predictive biomarkers and/or diagnostic development.
Preference will be given to candidates with experience and knowledge of dermatology, immunology and/or inflammatory disease.
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