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Job Details


Senior Scientist I / Senior Scientist II, Pharmacology



Full Time

On Site


Cambridge, Massachusetts, United States

Job Description

Over 40 therapies in the clinic! NIBR Oncology strives to reimagine medicines for cancer patients through a combination of treatment approaches including targeted therapies, immunotherapies, CAR-T, and radioligand therapy. NIBR is seeking an in vivo scientist to join our Oncology Pharmacology team in Cambridge, MA. The successful candidate will join a dynamic, multi-disciplinary team and play a key role in the development and application of in vivo models for evaluating novel cancer therapies and advancing the early-stage drug discovery pipeline. The primary responsibility of this position will be to craft and complete in vivo anti-tumor efficacy and PK/PD studies aimed at evaluating novel drug candidates in CDX, PDX, and syngeneic models. Qualified applicants will be proficient in animal handling techniques and compound administration, while possessing a variety of molecular biology and flow cytometric skills. In addition, qualified candidates will be highly motivated, inquisitive, and creative individuals, who thrive in a highly-matrixed work environment, and can optimally communicate within multidisciplinary project teams.

Your responsibilities include, but are not limited to:

- Design and execution of pre-clinical in vivo studies to explore novel hypotheses, evaluate candidate molecules, establish proof-of-concept, and investigate mechanism-of-action

- Develop in vivo CDX, PDX, and syngeneic models to evaluate anti-tumor activity, PK/PD relationships, and relevant biomarkers of novel compounds to support clinical development

- Work independently and collaborate with cross-functional project teams to execute studies

- Critically analyze and present results within a multidisciplinary team environment

- Careful adherence to animal protocols and proper documentation of data and methods in electronic laboratory notebook

This position will be located at the Cambridge, MA site and will not have the ability to be located remotely. This position will not require travel as defined by the business (domestic and/ or international).