Investigator, Biocatalysis Chemistry

Site Name: USA - Pennsylvania - Upper Providence
Posted Date: Apr 24 2023

GSK is a world leading research-based pharmaceutical company that combines both individual talent & technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better, & live longer.

An exciting opportunity has arisen in GSK’s Enzyme Evolution and Biocatalysis group. The primary focus of this role is to support the discovery and implementation of novel enzyme-based chemistry at GSK. This role is fast-paced and dynamic, you will thrive in this environment if you are able to effectively manage multiple priorities, communicate your recommendations clearly, and enjoy working in teams. 

Key responsibilities:

• Identify new opportunities to apply biocatalysis across GSK’s portfolio. Creative thinking is highly encouraged!
• Support our enzyme discovery and directed evolution platform.

• Work in a matrix team of medicinal chemists, process chemists, and engineers to develop novel biocatalytic solutions.
• Develop appropriate surrogates for process conditions to authentically replicate target process conditions in high throughput.
• Express, test, and rank enzyme variants in both microtiter plate and preparative scales.
• Work as part of a diverse team of scientists, including molecular biologists, bioinformaticians, and process chemists, to deliver evolved enzymes.
• Manipulate large-scale datasets using MS Excel, TIBCO Spotfire, and bespoke software tools.
• Liaise with scientists & external collaborators at all levels

Basic qualifications:

• Ph.D. in Chemistry, Biochemistry, Chemical Biology, or related field.
• Min. 1 year experience in the discovery and development of organic and biocatalytic reactions.
• Min. 1 year experience in enzyme characterization including a background in mechanistic and kinetic studies of enzymatic reactions (Vmax, Km, product inhibition, substrate inhibition, cofactors, redox chemistry).

Preferred qualifications:

• Significant experience in the discovery, development, and scale-up of enzyme catalyzed reactions.
• Experience with nucleic acid chemistry (e.g. solid phase synthesis, liquid phase synthesis, synthesis of unnatural nucleosides).
• Experience with parallel experimentation, high throughput assay development, and Design of Experiments.
• Experience in the development of miniaturized biochemical assays to drive enzyme evolution toward conditions relevant to industrial manufacturing.
• Understanding of protein engineering/expression tools and techniques.
• Familiarity with or interest in learning automation equipment.
• Demonstrated ability to work in multi-disciplinary teams, with excellent interpersonal, organizational, and communication skills.

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Why GSK?

We’re combining the power of genetic and genomic insights into what causes disease, with the speed and scale of artificial intelligence and machine learning (AI/ML) to make better predictions about who a treatment might work for, and why. We believe this powerful combination of data and technology holds the key to fundamentally transforming medical discovery for the better, improving R&D success rates and shaping how even the most challenging diseases, like neurological conditions and cancer, can be both prevented and treated.​

In 2021 we delivered four major product approvals: Cabenuva for HIV, Jemperli for endometrial cancer, Xevudy for COVID-19 and Apretude, our new long-acting medicine for HIV prevention.​

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