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Job Details

GlaxoSmithKline (GSK)

Investigator, Biocatalysis Chemistry



Full Time

On Site


Collegeville, Pennsylvania, United States

Site Name: USA - Pennsylvania - Upper Providence
Posted Date: Apr 24 2023

GSK is a world leading research-based pharmaceutical company that combines both individual talent & technical resources to create a platform for the delivery of strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better, & live longer.

An exciting opportunity has arisen in GSK’s Enzyme Evolution and Biocatalysis group. The primary focus of this role is to support the discovery and implementation of novel enzyme-based chemistry at GSK. This role is fast-paced and dynamic, you will thrive in this environment if you are able to effectively manage multiple priorities, communicate your recommendations clearly, and enjoy working in teams. 

Key responsibilities:

  • Identify new opportunities to apply biocatalysis across GSK’s portfolio. Creative thinking is highly encouraged!
  • Support our enzyme discovery and directed evolution platform.
  • Work in a matrix team of medicinal chemists, process chemists, and engineers to develop novel biocatalytic solutions.
  • Develop appropriate surrogates for process conditions to authentically replicate target process conditions in high throughput.
  • Express, test, and rank enzyme variants in both microtiter plate and preparative scales.
  • Work as part of a diverse team of scientists, including molecular biologists, bioinformaticians, and process chemists, to deliver evolved enzymes.
  • Manipulate large-scale datasets using MS Excel, TIBCO Spotfire, and bespoke software tools.
  • Liaise with scientists & external collaborators at all levels

Basic qualifications:

  • Ph.D. in Chemistry, Biochemistry, Chemical Biology, or related field.
  • Min. 1 year experience in the discovery and development of organic and biocatalytic reactions.
  • Min. 1 year experience in enzyme characterization including a background in mechanistic and kinetic studies of enzymatic reactions (Vmax, Km, product inhibition, substrate inhibition, cofactors, redox chemistry).

Preferred qualifications:

  • Significant experience in the discovery, development, and scale-up of enzyme catalyzed reactions.
  • Experience with nucleic acid chemistry (e.g. solid phase synthesis, liquid phase synthesis, synthesis of unnatural nucleosides).
  • Experience with parallel experimentation, high throughput assay development, and Design of Experiments.
  • Experience in the development of miniaturized biochemical assays to drive enzyme evolution toward conditions relevant to industrial manufacturing.
  • Understanding of protein engineering/expression tools and techniques.
  • Familiarity with or interest in learning automation equipment.
  • Demonstrated ability to work in multi-disciplinary teams, with excellent interpersonal, organizational, and communication skills.



Why GSK?

We’re combining the power of genetic and genomic insights into what causes disease, with the speed and scale of artificial intelligence and machine learning (AI/ML) to make better predictions about who a treatment might work for, and why. We believe this powerful combination of data and technology holds the key to fundamentally transforming medical discovery for the better, improving R&D success rates and shaping how even the most challenging diseases, like neurological conditions and cancer, can be both prevented and treated.

In 2021 we delivered four major product approvals: Cabenuva for HIV, Jemperli for endometrial cancer, Xevudy for COVID-19 and Apretude, our new long-acting medicine for HIV prevention.

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