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Job Details

Merck & Co. Inc.

Senior Scientist – Translational Oncology Biology



Full Time

On Site


Boston, Massachusetts, United States

Job Description

The In Vivo Pharmacology – Oncology group within the Department of Quantitative Biosciences is seeking a Senior Scientist with a strong background in cancer biology to join our Boston-based Exploratory Discovery team. The successful candidate will have a track record of innovative and collaborative research, demonstrated through peer-reviewed publications. The candidate will be able to work independently and proactively to collaborate with colleagues across multiple disciplines. The primary responsibilities will be to develop and characterize in vitro and in vivo novel clinically translatable human cancer models, to deliver insights into cancer biology, inform our therapeutic strategies and assist in the identification and validation of novel drug discovery programs for the next generation of cancer therapies.


  • Establish robust 3D in vitro model systems from various human primary tumors and normal tissues.

  • Establish novel in vivo patient derived cancer models using preclinical species.

  • Characterize both in vitro and in vivo models by histology, multiplexed imaging, WES, RNAseq, and high dimensional flow cytometry.

  • Establish genetic modification of organoids using CRISPR technology to understand target biological function.

  • Contribute to the characterization and validation of novel compounds and/or therapeutic antibodies using in vitro, ex vivo and in vivo translational model systems.

  • Communicate data clearly and concisely to the appropriate teams and stakeholders.

  • Be able to thrive in a team environment.


  • Experience in the generation, maintenance, and biological characterization of in vitro 3D organoid culture.

  • Experience with preclinical oncology animal models to further develop and characterize novel in vivo translational models.

  • Experience with immunohistochemistry / image analysis, molecular biology, and flow cytometry.

  • Strong background and experience in oncology and immuno-oncology.

  • Demonstrated ability to function and communicate effectively in a multi-disciplinary environment and thrive in a team environment.

  • Excellent problem-solving, communication, and project management skills.

Education Requirements:

  • BS/BA degree with a minimum 7 years of industry experience; or an MS degree with 4 years of industry experience; or a PhD in the field of cancer biology / immuno-oncology with post-doctoral experience.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization.


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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

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Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

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Requisition ID:R129614