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Job Details

Merck & Co. Inc.

Principal Scientist, Biology-Discovery



Full Time

On Site


Boston, Massachusetts, United States

Job Description

Our Company's Neuroscience division is seeking a dynamic, risk-taking and team-oriented scientific leader for our Cambridge-based neuroimmunology early discovery research team that will explore the essential role of microglia cells in defining the risk for CNS diseases of highest unmet need such as Alzheimer’s disease, Parkinson’s disease and ALS. The successful candidate will join us to grow a cross-functional team of talented scientists and drive the discovery of novel insights into innate immune biology with the objective to define and validate new therapeutic strategies to impact neurodegenerative diseases. Expertise in molecular and cellular neuroscience, neuroimmunology, pharmacology and a passion for translating basic science to therapeutics are required, coupled with a publication record reflective of scientific excellence. Demonstrated success in discovering, validating and progression of a pipeline of novel target concepts through data driven decision making are key attributes for this position. You will develop research strategies and priorities with your colleagues as a positive and authentic motivator and mentor with an ability to collaborate both within and outward of our Research & Development Division.

This position will oversee the generation and integration of multi-modal datasets using technologies such as single cell sequencing approaches, spatial transcriptomics, proteomics and lipidomics which will require a strong working knowledge of systems biology approaches. The successful candidate will have strong experimental design and execution skills and must be willing to apply them as part of the team. This position will be located at our Company’s growing Cambridge-based research facility that is adjacent to Kendall square. The Neuroimmunology lab will be integrated with colleagues in Chemical Biology, Genome and Biomarker Sciences, Oncology, Cardiometabolic diseases, Immunology, and our Exploratory Science Center as well as Neuroscience colleagues in Boston, London and West Point, PA.

Responsibilities include:

  • Conceptualizing and implementing an end-to-end research strategy with flexibility to rapidly adapt using data driven decision making

  • Being able to Integrate both in vitro and in vivo strategies

  • Managing multiple direct reports via positive motivation through clear and transparent communication and mentorship

  • Be a clear and fluid communicator of strategy and data to teams and stakeholders in written and oral form.

  • Monitor, review and critically interpret published literature to guide strategy

  • Be willing and able to engage hands-on with team members to develop, execute and troubleshoot experimental strategies

  • Proactively engage with members from diverse functional areas and global Neuroscience at Merck as well as develop external collaborations with academic and biotechnology partners that meaningfully amplify questions asked and capabilities applied.

Required Education:

  • PhD or MD/PhD preferably in Neuroscience, Pharmacology or Biochemistry or a related subject area with a minimum of 6 years of experience in industry, academia or biotechnology

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.

Invent. Impact. Inspire.


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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

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Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

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Requisition ID:R123480