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Merck & Co. Inc.

Postdoctoral Research Fellow – Multiscale Modeling of Biotherapeutics and Vaccines



Full Time

On Site


Rahway, New Jersey, United States

Job Description

Be a part of the legacy: Postdoctoral Research Fellow Program

Our Research Laboratories’ Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.

What You'll Be Doing:

The Preformulation-Predictive Sciences group develops creative and novel solutions to address significant unmet needs in the biopharmaceutical drug product development space. The Preformulation organization is continuing to build key scientific expertise in computational modeling of key molecular and macroscopic protein processes. Thus, we are seeking a highly motivated and driven postdoctoral individual that will lead the development of the next-generation computational and statistical tools to predict and mitigate physical instability challenges in protein-based formulations. The successful candidate will work in an interdisciplinary environment, contributing to cross-functional teams and gaining insight into many aspects of biotherapeutic and vaccine discovery, development and manufacturing. The Postdoctoral Fellow is expected to author scientific papers on their research and present novel findings at scientific conferences.

Responsibilities include but are not limited to:

  • Develop molecular and mesoscale protein models to characterize pertinent thermodynamic and kinetic problems in drug products.

  • Leverage novel molecular algorithms and existing modeling software to computationally simulate relevant molecular and macroscopic phenomena in proteins.

  • Handle and process large experimental and computational data sets for model training and validation.

  • Lead or facilitate meetings with both internal and external collaborators and participate in cross-functional teams at project-related topics.

  • Publish results in peer-reviewed journals and present in both internal and external scientific conferences.

What You Bring:

  • Candidates must currently hold a PhD OR receive a PhD by fall in Bioinformatics, Biophysics, Physical or Computational Chemistry, Physics, Chemical Engineering, or related fields.

  • High flexibility and adaptability to further develop and learn new skills in a dynamic work environment.

  • Proficiency in at least one of the following programming languages: Fortran, C, C++, Python, or R is required.

  • Strong interest in learning the development and execution of both traditional and advanced computational molecular simulation methods.

  • Strong oral and written communication skills and a proven track-record in scientific publications.

  • Desire for learning protein physics and instability phenomena associated to protein solutions.

  • Experience or the motivation for learning Statistical Thermodynamics and Hydrodynamics principles applied to biomolecules, polymers or colloids.

  • Knowledge of basic principles behind biophysical, biochemical, and/or molecular biological experimental methods in proteins is a plus.

  • A strong passion to drive cutting edge science and collaborations for the benefit of patients around the world.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us—and start making your impact today.


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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

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Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

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Requisition ID:R129565