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Job Details

GlaxoSmithKline (GSK)

Investigator -Nucleic Acid Biochemist



Full Time

On Site


Collegeville, Pennsylvania, United States

Site Name: USA - Pennsylvania - Upper Providence
Posted Date: May 9 2023

Nucleic Acid Biochemist (Investigator)

An exciting opportunity has arisen in the GSK Enzyme Engineering and Biocatalysis group for a nucleic acid biochemist.  As a nucleic acid biochemist supporting our enzyme evolution platform, you would be responsible for supporting our work developing new enzymes for the production and modification of nucleic acid products with applications across the full GSK portfolio. Working closely with project teams, you would develop assays for understanding and improving enzymes of interest, identify novel enzymes for the synthesis of complex oligonucleotide products, and help support enzyme evolution programs as part of an interdisciplinary team of experts.

The role is fast-paced and dynamic, you will thrive in this environment if you are able to effectively manage multiple priorities, communicate your recommendations clearly and enjoy working in teams.

Key responsibilities:

As a Nucleic Acid Biochemist, you will be responsible for a wide range of activities supporting our directed evolution workflow on a variety of protein engineering activities. Activities include:

  • Identifying new polymerase, ligase, and other DNA-engaging enzyme opportunities to support our portfolio

  • Generating libraries of enzyme variants for high throughput expression

  • Developing appropriate assays to screen and identify improved enzyme variants in high throughput

  • Designing experiments, collecting and analyzing data using programs such as MS Excel, TIBCO Spotfire and bespoke software tools to inform decisions

  • Supporting scale up activities for generation and use of enzymes

  • Interacting with partners in discovery, development, and manufacturing to identify and pursue enzyme opportunities

  • Generating conclusion reports, presenting data in team meetings & participating in writing of abstracts & publications

  • Conducting scientific work programs and making contributions both independently and as a member of a team with other R&D staff

  • Maintaining customer focus, motivating self, and demonstrating a high degree of urgency

  • Exhibiting flexibility, being open to new ways of working


Why you?

Basic Qualifications: 

  • Bachelor’s degree and 6 years of experience

  • Min. 2 experience with nucleic acid-modifying enzymes such as polymerases, ligases, and nucleases

  • Min. 2 experience with the identification of enzymes to perform reactions of interest, and the optimization of those enzymes under synthetically relevant conditions

Preferred qualifications:

  • Doctoral/PhD degree in Biochemistry, Chemical Biology, Synthetic Biology or related discipline OR

  • Master’s degree and 4 years of experience

  • Experience with parallel experimentation, high throughput assay development, Design of Experiments, etc.

  • Demonstrated ability to work in multi-disciplinary teams, displaying excellent interpersonal, organizational, and communication skills

  • Familiarity with lab automation equipment and its use in high throughput experimentation

  • Ability to analyze and visualize large multidimensional datasets

  • Experience in high throughput recombinant enzyme assays

  • Experience with qPCR, LC-MS, capillary electrophoresis, and Next Generation Sequencing (NGS)

  • Demonstrated excellence in the end-to-end execution of directed evolution projects including enzyme identification, library design, generation, and screening



Why GSK?

We’re combining the power of genetic and genomic insights into what causes disease, with the speed and scale of artificial intelligence and machine learning (AI/ML) to make better predictions about who a treatment might work for, and why. We believe this powerful combination of data and technology holds the key to fundamentally transforming medical discovery for the better, improving R&D success rates and shaping how even the most challenging diseases, like neurological conditions and cancer, can be both prevented and treated.

In 2021 we delivered four major product approvals: Cabenuva for HIV, Jemperli for endometrial cancer, Xevudy for COVID-19 and Apretude, our new long-acting medicine for HIV prevention.

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