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Job Details

Merck & Co. Inc.

Associate Principal Scientist



Full Time

On Site


Boston, Massachusetts, United States

Job Description

The Quantitative Biosciences, Boston department is seeking a highly motivated, talented, and experienced In-Vitro Associate Principal Scientist to join our High Content Imaging (HCI) group. The preferred candidate will be responsible for the design, development, and implementation of High Content Imaging and multiparametric assays using Cell painting, 3D imaging, live cell imaging platforms and computational algorithms to analyses images and interrogate multiparametric multiplex data.

The applicant will be executing on large scale experimentation protocols using pharmacological and genetic manipulation of cellular targets and pathways to characterize the molecular mode of action of small molecules and biologics. The candidate is expected to work independently and to proactively collaborate with colleagues in Quantitative Biosciences, IT, and across disciplines. Advanced oral and written communication skills are a must.

The specific responsibilities of the candidate include but are not limited to:

  • Design, develop and execute on multiparametric high-content cell-based assays in support of project assays and to define target engagement, functional responses, mechanisms of action and biomarkers for small molecules and bio-therapeutic agents of interest.

  • Conduct the computational analysis of high-content multiparametric readouts using a variety of approaches to analysis utilizing commercial and internal software solutions.

  • Work in collaboration with the data analytic groups to build reliable strategies for multiparametric data analysis and data integration.

  • Participate in core teams, present results and ideas and provide scientific reports/ deliverables to research projects in multiple disease areas

  • Properly document and report the experimental findings and provide scientific reports to the manager and team members.

  • Work collaboratively within the QB department, IT, and across functional teams to support of research projects/programs at different discovery stages.

Education Minimum Requirement: BS degree with 12+ years or MS degree with 8+ years or PhD degree with 4+ years

Required Experience and Skills

  • Understands the drug discovery process and has significant experience in applications of high content imaging in support of drug discovery and target identification

  • In-depth knowledge and practical expertise with High Content Imaging technologies in assay development and troubleshooting

  • Hands-on experience with multiparametric high content imaging data analysis using software solutions such as PE Columbus, Image J, Cellomics Bioapp, Methaexpress, CellProfiler ets.

  • Experience in statistical analysis of multiparametric high content and high throughput experiments

  • Familiarity with the latest cell-based high throughput automated technologies.

  • Ability to provide efficient technical support for imaging instrumentation, analysis applications and associated software modules by closely working with vendors, IT and other support groups.

  • Excellent oral and written communication skills, including preparation of study reports, presentations, and manuscripts for publication in peer-reviewed scientific journals.

Preferred Experience and Skills

  • Experience with the Cell Painting or other HCI Phenotypic screening platforms.

  • Experience in programming in Python or R scripting languages for machine learning and predictive analysis

  • Application of AI and machine learning to image analysis, 3D image analysis and HCI data analysis

  • Experience with medium and high throughput automated screen execution in an academic or industrial setting.

  • Experience with large data sets processing and analysis using commercial software solutions like PE SpotFire, IDBS acitvitybase, or proprietary data base solutions.

  • Research and drug discovery working experience in multiple therapeutic areas, including immunology, oncology, and neuroscience.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.

Invent. Impact. Inspire.


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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

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Travel Requirements:

No Travel Required

Flexible Work Arrangements:

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1st - Day

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Requisition ID:R120605